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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 1
1978 1
1982 1
1983 2
1985 2
1986 2
1987 4
1988 5
1989 9
1990 3
1991 4
1992 12
1993 6
1994 7
1995 6
1996 11
1997 13
1998 8
1999 6
2000 12
2001 10
2002 9
2003 10
2004 13
2005 11
2006 8
2007 11
2008 13
2009 5
2010 10
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2012 18
2013 11
2014 15
2015 7
2016 15
2017 14
2018 15
2019 13
2020 19
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2022 14
2023 13
2024 6

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369 results

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Page 1
First-in-Class Small Molecule to Inhibit CYP11A1 and Steroid Hormone Biosynthesis.
Karimaa M, Riikonen R, Kettunen H, Taavitsainen P, Ramela M, Chrusciel M, Karlsson S, Rummakko P, Simola O, Wohlfahrt G, Hakulinen P, Vuorela A, Joensuu H, Utriainen T, Fizazi K, Oksala R. Karimaa M, et al. Mol Cancer Ther. 2022 Dec 2;21(12):1765-1776. doi: 10.1158/1535-7163.MCT-22-0115. Mol Cancer Ther. 2022. PMID: 36129801
We hypothesized that CYP11A inhibition might halt the synthesis of all steroid hormones, because CYP11A is the only enzyme that catalyses the first step of steroid hormone biosynthesis. ...ODM-208 was well tolerated with steroid hormone replacement. The toxicity findings w …
We hypothesized that CYP11A inhibition might halt the synthesis of all steroid hormones, because CYP11A is the only enzyme that catal …
Exploring vitamin D metabolism and function in cancer.
Jeon SM, Shin EA. Jeon SM, et al. Exp Mol Med. 2018 Apr 16;50(4):1-14. doi: 10.1038/s12276-018-0038-9. Exp Mol Med. 2018. PMID: 29657326 Free PMC article. Review.
In addition, recent studies have revealed that vitamin D can also be metabolized and activated through a CYP11A1-driven non-canonical metabolic pathway. Numerous anticancer properties of vitamin D have been proposed, with diverse effects on cancer development and progressi …
In addition, recent studies have revealed that vitamin D can also be metabolized and activated through a CYP11A1-driven non-canonical …
A Review on CYP11A1, CYP17A1, and CYP19A1 Polymorphism Studies: Candidate Susceptibility Genes for Polycystic Ovary Syndrome (PCOS) and Infertility.
Heidarzadehpilehrood R, Pirhoushiaran M, Abdollahzadeh R, Binti Osman M, Sakinah M, Nordin N, Abdul Hamid H. Heidarzadehpilehrood R, et al. Genes (Basel). 2022 Feb 5;13(2):302. doi: 10.3390/genes13020302. Genes (Basel). 2022. PMID: 35205347 Free PMC article. Review.
The most important genes that play a role in the aetiology of PCOS are CYP11A1, CYP17A1, and CYP19A1. We evaluated the occurrence of polymorphisms in various ethnicities in the CYP11A1, CYP17A1, and CYP19A1 genes and their efficacy on increasing PCOS risk with infer …
The most important genes that play a role in the aetiology of PCOS are CYP11A1, CYP17A1, and CYP19A1. We evaluated the occurrence of …
Cuproptosis-related gene FDX1 expression correlates with the prognosis and tumor immune microenvironment in clear cell renal cell carcinoma.
Wang T, Liu Y, Li Q, Luo Y, Liu D, Li B. Wang T, et al. Front Immunol. 2022 Sep 26;13:999823. doi: 10.3389/fimmu.2022.999823. eCollection 2022. Front Immunol. 2022. PMID: 36225932 Free PMC article.

The findings of multivariate and univariate analyses illustrated that the OS in ccRCC patients with low FDX1 expression is shorter than in patients with high FDX1 expression (p < 0.05). Ferredoxin reductase and CYP11A1 are key proteins interacting with the FDX1 gene, an

…
The findings of multivariate and univariate analyses illustrated that the OS in ccRCC patients with low FDX1 expression is shorter than in p …
CYP11A1-derived vitamin D hydroxyderivatives as candidates for therapy of basal and squamous cell carcinomas.
Slominski AT, Brożyna AA, Kim TK, Elsayed MM, Janjetovic Z, Qayyum S, Slominski RM, Oak ASW, Li C, Podgorska E, Li W, Jetten AM, Tuckey RC, Tang EKY, Elmets C, Athar M. Slominski AT, et al. Int J Oncol. 2022 Aug;61(2):96. doi: 10.3892/ijo.2022.5386. Epub 2022 Jul 1. Int J Oncol. 2022. PMID: 35775377 Free PMC article.
Hydroxyderivatives of vitamin D3, including classical 1,25(OH)(2)D3 and novel CYP11A1-derived hydroxyderivatives, exert their biological activity by acting as agonists on the vitamin D receptor (VDR) and inverse agonists on retinoid-related orphan receptors (ROR)alpha and …
Hydroxyderivatives of vitamin D3, including classical 1,25(OH)(2)D3 and novel CYP11A1-derived hydroxyderivatives, exert their biologi …
Adipocyte and steroidogenic cell cross-talk in polycystic ovary syndrome.
de Medeiros SF, Rodgers RJ, Norman RJ. de Medeiros SF, et al. Hum Reprod Update. 2021 Jun 22;27(4):771-796. doi: 10.1093/humupd/dmab004. Hum Reprod Update. 2021. PMID: 33764457 Review.
Leptin expression positively correlates with body mass index, waist/hip ratio and levels of total cholesterol, triglyceride, luteinising hormone, oestradiol and androgens. Leptin inhibits the production of oestradiol and, in granulosa cells, may modulate 17-hydroxylase and …
Leptin expression positively correlates with body mass index, waist/hip ratio and levels of total cholesterol, triglyceride, luteinis …
Single-Cell RNA-Seq Identifies Pathways and Genes Contributing to the Hyperandrogenemia Associated with Polycystic Ovary Syndrome.
Harris RA, McAllister JM, Strauss JF 3rd. Harris RA, et al. Int J Mol Sci. 2023 Jun 25;24(13):10611. doi: 10.3390/ijms241310611. Int J Mol Sci. 2023. PMID: 37445796 Free PMC article.
Results from these studies revealed differentially expressed pathways and genes involved in the acquisition of cholesterol, the precursor of steroid hormones, and steroidogenesis. ...The expression profiles appear to be directed largely by increased levels or activity of t …
Results from these studies revealed differentially expressed pathways and genes involved in the acquisition of cholesterol, the precu …
Statistics of Rare Events.
Proschan MA, Kherabi Y. Proschan MA, et al. NEJM Evid. 2024 Jan;3(1):EVIDe2300303. doi: 10.1056/EVIDe2300303. Epub 2023 Dec 26. NEJM Evid. 2024. PMID: 38320520
Rare events can sometime arise in clinical development of treatments. For example, CYPIDES was a single-arm study of the CYP11A1 inhibitor ODM-208 to treat metastatic prostate cancer.(1) Preclinical testing of the compound identified elevated thyroid-stimulating hormone (T …
Rare events can sometime arise in clinical development of treatments. For example, CYPIDES was a single-arm study of the CYP11A1 inhi …
Genetic variation in CYP11A1 and StAR in relation to endometrial cancer risk.
Terry K, McGrath M, Lee IM, Buring J, De Vivo I. Terry K, et al. Gynecol Oncol. 2010 May;117(2):255-9. doi: 10.1016/j.ygyno.2010.02.002. Epub 2010 Mar 2. Gynecol Oncol. 2010. PMID: 20199803 Free PMC article.
OBJECTIVE: Together, steroidogenic acute regulator (StAR) and the cholesterol side chain cleavage enzyme (P450scc), which is encoded by CYP11A1, mediate the initial and rate-limiting step in steroidogenesis. ...CONCLUSIONS: Genetic varian …
OBJECTIVE: Together, steroidogenic acute regulator (StAR) and the cholesterol side chain cleavage enzyme …
Common polymorphisms in the CYP1A1 and CYP11A1 genes and polycystic ovary syndrome risk: a meta-analysis and meta-regression.
Shen W, Li T, Hu Y, Liu H, Song M. Shen W, et al. Arch Gynecol Obstet. 2014 Jan;289(1):107-18. doi: 10.1007/s00404-013-2939-0. Epub 2013 Jul 13. Arch Gynecol Obstet. 2014. PMID: 23852617
CONCLUSION: Our meta-analysis suggests that CYP1A1 MspI and CYP11A1 microsatellite [TTTA]n repeat polymorphisms may contribute to increasing susceptibility to PCOS among Caucasian populations. Detection of common polymorphisms in the CYP1A1 and CYP11A1 genes might b …
CONCLUSION: Our meta-analysis suggests that CYP1A1 MspI and CYP11A1 microsatellite [TTTA]n repeat polymorphisms may contribute to inc …
369 results